CASE REPORTS Methysergide-induced Heart Disease A Case of Multivalvular and Myocardial Fibrosis

METHYSERGIDE, an anti-serotonin agent used for prophylaxis of migraine headaches, produces mitral and aortic valvular fibrosis resulting in valvular dysfunction. '-7 This study reports a unique case both of hemodynamically significant right-sided valvular disease and of intramyocardial fibrosis (diagnosed by transvenous cardiac biopsy) resulting from methysergide administration. Our patient represents the first reported case of cardiac toxicity developing during interrupted (noncontinuous) methysergide therapy.